I don't think you *can* shoot anything but manually with strobes, can you? I mean, you could, but, nothing would turn out. I have a sekonic meter, but, have to admit to not using it very often. I pretty much know what settings I am going to be at depending on my light settings. It has been a lot of trial and error though

And like Jim says, there are a million answers on HOW to set up your lights, but, it all just depends on what you want the end product to look like. All depends on your subject too.