Now, no. Eventually, yes. I have had small issues but annoying ones with Vista Ultimate 64 bit, which by the way is all my monster machine (D10) will run on. I also run XP and XP pro on my other machines. Not nearly the issues but still have some. The main reason I will upgrade is Vista support will go away. The only things I really care about with my OS are stability and compatibility and networking. I use external applications for everything I do.