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With the high ISO's, how do you prevent noise or is that an issue?




The way to minimize noise is to get the exposure right. A bit of over exposure, provided you don't completely blow the highlights is optimum. I'll blow a white patch on a black dog to get the exposure right for the black.

A good noise reduction program / plug-in will go a long way as well.

In indoor environments with crappy lighting, my personal opinion is that shooting in anything but RAW is nuts.